Herpes simplex viruses(HSV) are one of the most common infectious virus of man.
Though chemotherapies and antibiotics against HSV have been developed in many countries, but anti-HSV agents were not satisfactory to mankind by their toxic reaction and side effects. In order to search for anti-HSV agents from
Korean
traditional prescriptions, we extended the number of specimens. Both methanol extract and boiling water extract of the Koreantraditional prescriptions were screened to detect anti-HSV activities by MTT assay.
Korean traditional prescriptions showing anti-HSV activities as methanol extracts were Paekyopsan, Chesupwilyungtang, Yongdamsagantang, and prescription 11. Four methanol extracts showing anti-HSV activities were fractionated by
hexane
and their efficacies were tested. Hexane fractionations of Paekyopsan, Chesupwilyungtang, and prescription 11 showed in anti-HSV activities in tissue culture and their selectivity indexes (SI) were 19.50, 3.32 and
42.90, respectively. Methanol fractionation of Paekyopsan showed anti-HSV activities and its SI was 1.40. Especially Paekyopsan showed anti-HSV activities both haxane and methanol fractionation.
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